Research Centre Information Centre AgeFactDB
Release 1 - Aug 15, 2013



Ageing factors are genes, chemical compounds or other factors such as dietary restriction or overfeeding, heat shock, low temperature and so on that have an effect on lifespan and/or ageing phenotype. Information related to these effects of ageing factors is called an observation and is presented in the database on observation pages. Information reported in one paper can lead to one or more observations. To provide an easy and compact access to the complete information for a particular gene or a specific compound or for one of the other factors the corresponding observations are also summarized on ageing factor pages. Based on a comprehensive homology analysis, AgeFactDB provides, in addition to known ageing-related genes, a compilation of genes that are orthologous to these known genes. These orthologs can be considered as candidate or putative ageing-related genes. The fact that genes are orthologous to each other is also viewed as an observation. So, the ageing relevance can be derived either from experimental or from computational studies. Whereas observations are always either computational or experimental for ageing factors it may happen that there is both experimental and computational evidence.

Ageing Factors

Ageing Relevance Evidence
Type Experimental Computational Both Any
Gene 2594 14437 581 16450
Compound 91 - - 91
Other Ageing Factor 58 - - 58
Ageing Factors 2743 14437 581 16599


Ageing Relevance Evidence
Type Experimental Computational Both Any
Ageing Phenotype 8159 - - 8159
Data Type 1 940 - - 940
Data Type 2 7219 - - 7219
Homology Analysis - 1452 - 1452
Observations 8159 1452 - 9611